Product Description: mature parasite-infected erythrocyte surface antigen
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0020002 | host cell plasma membrane |
| Component | GO:0020030 | infected host cell surface knob |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.86 | 0.72 |
| Trophozoite | expressed | 3.71 | 0.05 |
| Schizont | expressed | 1.15 | 0.55 |
| Gametocyte | not expressed | 0.34 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0500800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.237 | #Insertions: 7
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: P08116
"Best" AlphaFill ligand hit: 2NV (jeffamine ed-2001, Local RMSD=23.29) with 6VJ6 (Global RMSD=31.75)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 20 | 5 | 28 |
| disruptive | 37 | 85 | 29 | 100 |
| missense | 25 | 66 | 23 | 82 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 31 | 14 | 30 |
| disruptive | 69 | 159 | 57 | 119 |
| missense | 45 | 110 | 39 | 90 |
PlasmoDB Total SNPs: 442
Non-coding: 103 | Synonymous: 247 | Nonsynonymous: 92 | Stop Codon: 0
Protein Length: 1434 | Molecular Weight (kDa): 168.288
UniProt ID(s): P08116, Q06166, Q06167, Q25920, Q86BT4, Q86BT5, Q86BT6, Q86BT7, Q8I492, Q9GVB1, Q9NB35
PDB ID(s): None
Isoelectric Point: 4.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR009484 | Protein of unknown function DUF1103 |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| PFam | PF00226 | DnaJ domain |
| PFam | PF06513 | Protein of unknown function DUF1103 |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 3065643 | MESA is a Plasmodium falciparum phosphoprotein associated with the erythrocytemembrane skeleton. | Coppel RL, Lustigman S, Murray L, Anders RF | 10.1016/0166-6851(88)90152-1 |
| 3278227 | Two approximately 300 kilodalton Plasmodium falciparum proteins at the surfacemembrane of infected erythrocytes. | Howard RJ, Barnwell JW, ..., Saul A | 10.1016/0166-6851(88)90040-0 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15477199 | Myosin-like sequences in the malaria parasite Plasmodium falciparum bind humanerythrocyte membrane protein 4.1. | Lanzillotti R, Coetzer TL | https://pubmed.ncbi.nlm.nih.gov/15477199/ |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18482775 | In vivo studies support the role of trafficking and cytoskeletal-binding motifsin the interaction of MESA with the membrane skeleton of Plasmodiumfalciparum-infected red blood cells. | Black CG, Proellocks NI, ..., Coppel RL | 10.1016/j.molbiopara.2008.04.001 |
| 28252383 | Plasmodium falciparum parasites deploy Rhop H2 into the host erythrocyte to obtainnutrients, grow and replicate | Counihan NA, Chisholm SA, ..., de Koning-Ward TF | 10.7554/eLife.23217 |
| 28981210 | Proteome and Structural Organization of the Knob Complex on the Surface of thePlasmodium Infected Red Blood Cell. | Alampalli SV, Grover M, ..., Acharya P | 10.1002/prca.201600177 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31125575 | The Plasmodium falciparum MESA erythrocyte cytoskeleton-binding (MEC) motif bindsto erythrocyte ankyrin. | Kilili GK, Shakya B, ..., LaCount DJ | 10.1016/j.molbiopara.2019.111189 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 33774908 | Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. | Jonsdottir TK, Counihan NA, ..., Gilson PR | 10.1111/cmi.13332 |