About Gene List

PF3D7_0501000

Genome location: Pf3D7_05_v3:55,122..57,159(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:1903561 extracellular vesicle
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.73 0.68
Trophozoite expressed 1.34 0.41
Schizont expressed 0.17 0.90
Gametocyte possibly expressed 0.14 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0501000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.979 | MFS: -0.91 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I490

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532871

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 11 4 14
disruptive 9 14 9 29
missense 9 14 9 27

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 15 4 15
disruptive 12 43 26 57
missense 11 34 24 37

PlasmoDB Total SNPs: 87

Non-coding: 72 | Synonymous: 7 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 260 | Molecular Weight (kDa): 30.716

UniProt ID(s): Q8I490

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
15671043 Proteomic analysis identifies novel proteins of the Maurer's clefts, a secretorycompartment delivering Plasmodium falciparum proteins to the surface of its hostcell. Vincensini L, Richert S, ..., Braun Breton C 10.1074/mcp.M400176-MCP200
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
28944300 Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. Abdi A, Yu L, ..., Rayner J 10.12688/wellcomeopenres.11910.2
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
33774908 Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. Jonsdottir TK, Counihan NA, ..., Gilson PR 10.1111/cmi.13332