Product Description: heat shock protein 40, type II, co-chaperone J domain protein JDP
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0044164 | host cell cytosol |
| Function | GO:0001671 | ATPase activator activity |
| Function | GO:0051087 | chaperone binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0051085 | chaperone cofactor-dependent protein refolding |
| Process | GO:0032781 | positive regulation of ATP-dependent activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | not expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0501100.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.166 | MFS: -2.499 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0310000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZY16
"Best" AlphaFill ligand hit: 1PS (3-pyridinium-1-ylpropane-1-sulfonate, Local RMSD=1.27) with 5AYK (Global RMSD=8.47)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P31689 | DnaJ homolog subfamily A member 1 | Homo sapiens | OrthoDB | CHEMBL52073CHEMBL159171 |
Ortholog Group (OrthoMCL): OG6_100302
Most Similar Human Ortholog: A0A7I2YQW1
TM-align score: 0.86 | RMSD: 1.03
Seq Identity: 0.31 | Length: 48 / 402
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000132002 | DnaJ heat shock protein family (Hsp40) member B1 |
| ENSG00000137094 | DnaJ heat shock protein family (Hsp40) member B5 |
| ENSG00000162616 | DnaJ heat shock protein family (Hsp40) member B4 |
| ENSG00000187726 | DnaJ heat shock protein family (Hsp40) member B13 |
Protein Length: 402 | Molecular Weight (kDa): 46.367
UniProt ID(s): Q8I489
PDB ID(s): None
Isoelectric Point: 7.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR002939 | Chaperone DnaJ, C-terminal |
| InterPro | IPR008971 | HSP40/DnaJ peptide-binding |
| InterPro | IPR018253 | DnaJ domain, conserved site |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| PFam | PF00226 | DnaJ domain |
| PFam | PF01556 | Chaperone DnaJ, C-terminal |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
| Superfamily | SSF49493 | HSP40/DnaJ peptide-binding |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 15 | 2 | 10 |
| disruptive | 6 | 14 | 5 | 34 |
| missense | 6 | 13 | 5 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 18 | 10 | 15 |
| disruptive | 13 | 43 | 23 | 76 |
| missense | 10 | 37 | 16 | 55 |
PlasmoDB Total SNPs: 136
Non-coding: 127 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 38418371 | Plasmodium falciparum J-dot localized J domain protein A8iJp modulates thechaperone activity of human HSPA8 | Sahu W, Bai T, ..., Reddy KS | 10.1002/1873-3468.14836 |
| 38377589 | The Regulatory Effect of Huangshui Polysaccharides on Intestinal Microbiota andMetabolites during In Vitro Fermentation | Li M, Su J, ..., Liang H | 10.1021/acs.jafc.3c08658 |