Product Description: parasite-infected erythrocyte surface protein
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0009986 | cell surface |
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0044228 | host cell surface |
| Component | GO:0005634 | nucleus |
| Function | GO:0046812 | host cell surface binding |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.34 | 0.85 |
| Trophozoite | expressed | 1.05 | 0.50 |
| Schizont | expressed | 0.11 | 0.94 |
| Gametocyte | not expressed | 0.11 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0501200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.988 | MFS: -2.573 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I488
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 6 | 3 | 9 |
| disruptive | 29 | 34 | 19 | 66 |
| missense | 24 | 25 | 11 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 12 | 8 | 17 |
| disruptive | 39 | 98 | 45 | 114 |
| missense | 28 | 66 | 35 | 51 |
PlasmoDB Total SNPs: 162
Non-coding: 104 | Synonymous: 43 | Nonsynonymous: 15 | Stop Codon: 0
Protein Length: 408 | Molecular Weight (kDa): 48.721
UniProt ID(s): Q8I488
PDB ID(s): None
Isoelectric Point: 7.17
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15287581 | Proteomics approach reveals novel proteins on the surface of malaria-infectederythrocytes. | Florens L, Liu X, ..., Wu Y | https://pubmed.ncbi.nlm.nih.gov/15287581/ |
| 15671043 | Proteomic analysis identifies novel proteins of the Maurer's clefts, a secretorycompartment delivering Plasmodium falciparum proteins to the surface of its hostcell. | Vincensini L, Richert S, ..., Braun Breton C | 10.1074/mcp.M400176-MCP200 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 25615740 | New Export Pathway in Plasmodium falciparum-Infected Erythrocytes: Role of theParasite Group II Chaperonin, PfTRiC. | Mbengue A, Vialla E, ..., Braun-Breton C | 10.1111/tra.12266 |
| 29100811 | Plasmodium falciparum exported protein PFE60 influences Maurer's cleftsarchitecture and virulence complex composition. | Zhang M, Faou P, Maier AG, Rug M | 10.1016/j.ijpara.2017.09.003 |
| 29162636 | Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum SurfaceAntigens and Possible Vaccine Candidates. | Nilsson Bark SK, Ahmad R, ..., Marti M | 10.1074/mcp.RA117.000076 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31476617 | A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infectedErythrocytes. | Takano R, Kozuka-Hata H, ..., Kato K | 10.1016/j.isci.2019.07.035 |
| 32184257 | Role of Plasmodium falciparum Protein G EXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum E MP1 Trafficking | McHugh E, Carmo OMS, ..., Dixon MWA | 10.1128/mBio.03320-19 |
| 33631268 | Identification of Plasmodium falciparum-specific protein PIESP2 as a novelvirulence factor related to cerebral malaria. | Liu X, Wu Y, ..., Liang J | 10.1016/j.ijbiomac.2021.02.145 |
| 34535134 | The prevalence and density of asymptomatic Plasmodium falciparum infections amongchildren and adults in three communities of western Kenya | Salgado C, Ayodo G, ..., Tran TM | 10.1186/s12936-021-03905-w |
| 29716542 | In-depth comparative analysis of malaria parasite genomes reveals protein-codinggenes linked to human disease in Plasmodium falciparum genome | Liu X, Wang Y, ..., Zhao G | 10.1186/s12864-018-4654-5 |