Product Description: skeleton-binding protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005737 | cytoplasm |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0020004 | symbiont-containing vacuolar space |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Function | GO:0005515 | protein binding |
| Process | GO:0015031 | protein transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.91 | 0.15 |
| Trophozoite | expressed | 0.75 | 0.66 |
| Schizont | expressed | 0.53 | 0.73 |
| Gametocyte | expressed | 0.30 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0501300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.196 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1101300)
Modification: Disrupted | RMgm-5130
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I487
"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=1.46) with 3R5C (Global RMSD=17.91)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.3.16 | protein-serine/threonine phosphatase | ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 172
Non-coding: 115 | Synonymous: 22 | Nonsynonymous: 35 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11087921 | Pfsbp1, a Maurer's cleft Plasmodium falciparum protein, is associated with theerythrocyte skeleton. | Blisnick T, Morales Betoulle ME, ..., Braun Breton C | 10.1016/s0166-6851(00)00301-7 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 17023587 | Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane totraffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface. | Maier AG, Rug M, ..., Cowman AF | 10.1182/blood-2006-08-043364 |
| 19054387 | Export of PfSBP1 to the Plasmodium falciparum Maurer's clefts. | Saridaki T, Frohlich KS, Braun-Breton C, Lanzer M | 10.1111/j.1600-0854.2008.00860.x |
| 25615740 | New Export Pathway in Plasmodium falciparum-Infected Erythrocytes: Role of theParasite Group II Chaperonin, PfTRiC. | Mbengue A, Vialla E, ..., Braun-Breton C | 10.1111/tra.12266 |
| 25883090 | Interactions between Plasmodium falciparum skeleton-binding protein 1 and themembrane skeleton of malaria-infected red blood cells. | Kats LM, Proellocks NI, ..., Cooke BM | 10.1016/j.bbamem.2015.03.038 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 29155505 | PHISTc protein family members localize to different subcellular organelles andbind Plasmodium falciparum major virulence factor PfEMP-1. | Kumar V, Kaur J, ..., Hora R | 10.1111/febs.14340 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 30576479 | Plasmodium falciparum protein ' PfJ23' hosts distinct binding sites for majorvirulence factor ' PfEMP1' and Maurer's cleft marker ' PfSBP1' | Kaur J, Kumar V, ..., Hora R | 10.1093/femspd/fty090 |
| 31356937 | CX3CL1 binding protein-2 (CBP2) of Plasmodium falciparum binds nucleic acids. | Saxena R, Kaur J, ..., Mishra PC | 10.1016/j.ijbiomac.2019.07.178 |
| 31476617 | A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infectedErythrocytes. | Takano R, Kozuka-Hata H, ..., Kato K | 10.1016/j.isci.2019.07.035 |
| 31669509 | Skeleton binding protein 1 (SBP1) of Plasmodium falciparum accumulates inelectron-dense material before passing through the parasitophorous vacuolemembrane. | Iriko H, Ishino T, ..., Tsuboi T | 10.1016/j.parint.2019.102003 |
| 37772444 | Time-resolved proximity biotinylation implicates a porin protein in export oftransmembrane malaria parasite effectors | Anaguano D, Dedkhad W, ..., Muralidharan V | 10.1242/jcs.260506 |
| 37000891 | Formation of ER-lumenal intermediates during export of Plasmodium proteinscontaining transmembrane-like hydrophobic sequences | Levray YS, Bana B, ..., Osborne AR | 10.1371/journal.ppat.1011281 |
| 38331312 | Skeleton binding protein 1 localizes to the Maurer's cleft and interacts withPfHSP70-1 and PfHSP70-x in Plasmodium falciparum gametocyte-infectederythrocytes | Omoda A, Matsumoto K, ..., Iriko H | 10.1016/j.parint.2024.102864 |