About Gene List

PF3D7_0501400 (FIRA)

Genome location: Pf3D7_05_v3:73,163..80,813(+)

Genome classification: Core

Function and Localization

Product Description: interspersed repeat antigen

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0005615 extracellular space
Function GO:0004867 serine-type endopeptidase inhibitor activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 2.71 0.20
Trophozoite expressed 0.65 0.69
Schizont expressed 0.77 0.58
Gametocyte expressed 0.48 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0501400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.032 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I486

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_114904

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 16 3 12
disruptive 51 86 24 95
missense 29 52 17 48

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 25 5 22
disruptive 77 124 40 123
missense 42 78 27 54

PlasmoDB Total SNPs: 1006

Non-coding: 81 | Synonymous: 503 | Nonsynonymous: 419 | Stop Codon: 3

Protein Information

Protein Length: 1720 | Molecular Weight (kDa): 189.54

UniProt ID(s): Q25884, Q8I486

PDB ID(s): None

Isoelectric Point: 4.17

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g
35889000 The Microbiome of the 'Williams' Pear Variety Grown in the Organic Orchard andAntifungal Activity by the Autochthonous Bacterial and Yeast Isolates Janakiev T, Beric T, ..., Dimkic I 10.3390/microorganisms10071282