Product Description: anaphase-promoting complex subunit 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005680 | anaphase-promoting complex |
| Component | GO:0005737 | cytoplasm |
| Process | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| Process | GO:0051301 | cell division |
| Process | GO:0030261 | chromosome condensation |
| Process | GO:0000910 | cytokinesis |
| Process | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle |
| Process | GO:0045842 | positive regulation of mitotic metaphase/anaphase transition |
| Process | GO:0016567 | protein ubiquitination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | not expressed | 0.04 | 0.98 |
| Schizont | not expressed | 0.06 | 0.96 |
| Gametocyte | not expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0501700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.314 | #Insertions: 5
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1101500)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1101500)
Modification: Tagged | RMgm-4433
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I483
"Best" AlphaFill ligand hit: MPO (3[n-morpholino]propane sulfonic acid, Local RMSD=0.83) with 4LXQ (Global RMSD=14.96)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101939
Most Similar Human Ortholog: I3L2Z8
TM-align score: 0.73 | RMSD: 2.67
Seq Identity: 0.05 | Length: 78 / 793
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000004897 | cell division cycle 27 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 22 | 12 | 25 |
| disruptive | 19 | 55 | 24 | 74 |
| missense | 12 | 48 | 21 | 65 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 40 | 18 | 33 |
| disruptive | 38 | 120 | 60 | 153 |
| missense | 21 | 94 | 46 | 114 |
PlasmoDB Total SNPs: 73
Non-coding: 0 | Synonymous: 47 | Nonsynonymous: 25 | Stop Codon: 1
Protein Length: 793 | Molecular Weight (kDa): 95.432
UniProt ID(s): Q8I483
PDB ID(s): None
Isoelectric Point: 7.23
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| InterPro | IPR019734 | Tetratricopeptide repeat |
| PFam | PF13181 | Tetratricopeptide repeat |
| Superfamily | SSF48452 | Tetratricopeptide-like helical domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 29618731 | Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypicalmitosis in male gametogenesis. | Wall RJ, Ferguson DJP, ..., Tewari R | 10.1038/s41598-018-23871-9 |