Product Description: chromatin assembly factor 1 subunit A
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000417 | HIR complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0042393 | histone binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0003714 | transcription corepressor activity |
| Process | GO:0006336 | DNA replication-independent chromatin assembly |
| Process | GO:0000070 | mitotic sister chromatid segregation |
| Process | GO:0031935 | obsolete regulation of chromatin silencing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.16 | 0.93 |
| Trophozoite | expressed | 1.09 | 0.46 |
| Schizont | expressed | 0.69 | 0.63 |
| Gametocyte | possibly expressed | 0.68 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0501800
Resistome Missense Mutations: G817D
Resistome Compounds with Missense Mutations: DDD107498
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.168 | MFS: -2.708 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I482
"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=6.71) with 4GM8 (Global RMSD=8.60)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102357
Most Similar Human Ortholog: Q13112
TM-align score: 0.63 | RMSD: 3.33
Seq Identity: 0.26 | Length: 389 / 1076
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000159259 | chromatin assembly factor 1 subunit B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 36 | 17 | 31 |
| disruptive | 33 | 87 | 41 | 96 |
| missense | 19 | 66 | 35 | 77 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 67 | 32 | 44 |
| disruptive | 62 | 187 | 83 | 225 |
| missense | 34 | 133 | 69 | 124 |
PlasmoDB Total SNPs: 286
Non-coding: 131 | Synonymous: 72 | Nonsynonymous: 83 | Stop Codon: 0
Protein Length: 1076 | Molecular Weight (kDa): 125.356
UniProt ID(s): Q8I482
PDB ID(s): None
Isoelectric Point: 4.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR031120 | WD repeat HIR1 |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 29183721 | Role of Chromatin assembly factor 1 in DNA replication of Plasmodium falciparum. | Gupta MK, Agarawal M, ..., Dhar SK | 10.1016/j.bbrc.2017.11.131 |
| 26180518 | Functional regulation of Zfp36l1 and Zfp36l2 in response to lipopolysaccharide inmouse RAW264.7 macrophages | Wang KT, Wang HH, ..., Chang CJ | 10.1186/s12950-015-0088-x |