Product Description: trafficking protein particle complex subunit 13, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.96 |
| Trophozoite | not expressed | 0.23 | 0.85 |
| Schizont | not expressed | 0.10 | 0.92 |
| Gametocyte | possibly expressed | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0501900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.59 | #Insertions: 5
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1101700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1101700)
Modification: Disrupted | RMgm-2923
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I481
"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=9.52) with 6JWX (Global RMSD=24.06)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 11 | 3 | 18 |
| disruptive | 8 | 24 | 11 | 57 |
| missense | 8 | 24 | 10 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 18 | 7 | 21 |
| disruptive | 12 | 62 | 32 | 83 |
| missense | 10 | 46 | 29 | 65 |
PlasmoDB Total SNPs: 123
Non-coding: 101 | Synonymous: 18 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 381 | Molecular Weight (kDa): 45.465
UniProt ID(s): Q8I481
PDB ID(s): None
Isoelectric Point: 8.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010378 | Trafficking protein particle complex subunit 13 |
| PFam | PF06159 | Trafficking protein particle complex subunit 13 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |