Product Description: vacuolar protein sorting-associated protein 11, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030897 | HOPS complex |
| Component | GO:0005768 | endosome |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Function | GO:0030674 | protein-macromolecule adaptor activity |
| Function | GO:0008270 | zinc ion binding |
| Process | GO:0007032 | endosome organization |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0035542 | regulation of SNARE complex assembly |
| Process | GO:0007033 | vacuole organization |
| Process | GO:0006904 | vesicle docking involved in exocytosis |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.46 | 0.78 |
| Trophozoite | expressed | 0.70 | 0.61 |
| Schizont | expressed | 0.38 | 0.77 |
| Gametocyte | possibly expressed | 0.30 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0502000
Resistome Missense Mutations: K524Q
Resistome Compounds with Missense Mutations: BI-2536
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.154 | MFS: -3.264 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I480
"Best" AlphaFill ligand hit: U5P (uridine-5'-monophosphate, Local RMSD=0.01) with 2QAF (Global RMSD=13.29)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102537
Most Similar Human Ortholog: A0A0G2JS92
TM-align score: 0.36 | RMSD: 5.28
Seq Identity: 0.13 | Length: 229 / 1272
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000160695 | VPS11 core subunit of CORVET and HOPS complexes |
| ENSG00000280616 | VPS11 core subunit of CORVET and HOPS complexes |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 61 | 36 | 60 |
| disruptive | 41 | 130 | 76 | 173 |
| missense | 35 | 120 | 62 | 155 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 104 | 40 | 65 |
| disruptive | 74 | 276 | 111 | 273 |
| missense | 57 | 223 | 94 | 202 |
PlasmoDB Total SNPs: 170
Non-coding: 66 | Synonymous: 50 | Nonsynonymous: 54 | Stop Codon: 0
Protein Length: 1272 | Molecular Weight (kDa): 151.643
UniProt ID(s): Q8I480
PDB ID(s): None
Isoelectric Point: 9.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016528 | Vacuolar protein sorting-associated protein 11 |
| InterPro | IPR024763 | Vacuolar protein sorting protein 11, C-terminal |
| PFam | PF12451 | Vacuolar protein sorting protein 11, C-terminal |
| Superfamily | SSF57850 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 34013567 | Homozygous missense VPS16 variant is associated with a novel disease, resemblingmucopolysaccharidosis-plus syndrome in two siblings | Yildiz Y, Kosukcu C, ..., Dursun A | 10.1111/cge.14002 |