PF3D7_0502100

Genome location: Pf3D7_05_v3:101,346..103,488(-)

Genome classification: Core

Function and Localization

Product Description: HCNGP-like protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.37	0.77
Schizont	not expressed	0.23	0.83
Gametocyte	not expressed	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0502100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -2.998 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I479

"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=15.31) with 4IV8 (Global RMSD=23.39)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104160

Most Similar Human Ortholog: J3QKW0

TM-align score: 0.31 | RMSD: 3.12

Seq Identity: 0.08 | Length: 26 / 234

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000161526	SAP30 binding protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	12	4	14
disruptive	10	25	16	30
missense	9	25	15	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	20	5	9
disruptive	17	59	28	63
missense	15	50	22	34

PlasmoDB Total SNPs: 41

Non-coding: 31 | Synonymous: 3 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 234 | Molecular Weight (kDa): 27.84

UniProt ID(s): Q8I479

PDB ID(s): None

Isoelectric Point: 4.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012479	SAP30-binding protein
PFam	PF07818	SAP30-binding protein
Superfamily	N/A	N/A