Product Description: protein Mpv17, putative
SignalP Peptide: N/A
# Transmembrane Domains: 5
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.14 | 0.93 |
| Trophozoite | expressed | 0.46 | 0.72 |
| Schizont | expressed | 0.43 | 0.73 |
| Gametocyte | expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0502200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.137 | MFS: -2.922 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1102000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I478
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100380
Most Similar Human Ortholog: P39210
TM-align score: 0.86 | RMSD: 2.46
Seq Identity: 0.24 | Length: 174 / 443
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115204 | mitochondrial inner membrane protein MPV17 |
| ENSG00000176894 | peroxisomal membrane protein 2 |
| ENSG00000254858 | MPV17 mitochondrial inner membrane protein like 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 20 | 7 | 17 |
| disruptive | 8 | 45 | 26 | 63 |
| missense | 8 | 44 | 25 | 53 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 35 | 7 | 25 |
| disruptive | 27 | 105 | 57 | 122 |
| missense | 19 | 90 | 47 | 79 |
PlasmoDB Total SNPs: 94
Non-coding: 63 | Synonymous: 24 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 443 | Molecular Weight (kDa): 53.226
UniProt ID(s): Q8I478
PDB ID(s): None
Isoelectric Point: 10.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007248 | Mpv17/PMP22 |
| PFam | PF04117 | Mpv17/PMP22 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 36899826 | Mitochondrial Metabolomics of Sym1-Depleted Yeast Cells Revealed Them to BeLysine Auxotroph | Lagies S, Pan D, ..., Kammerer B | 10.3390/cells12050692 |
| 36791826 | Methylglyoxal-mediated Gpd1 activation restores the mitochondrial defects in ayeast model of mitochondrial DNA depletion syndrome | Mukherjee S, Das S, ..., Ghosh A | 10.1016/j.bbagen.2023.130328 |