PF3D7_0502300

Genome location: Pf3D7_05_v3:106,583..108,202(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.03	0.98
Gametocyte	expressed	1.08	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0502300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.943 | MFS: -2.528 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I477

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532428

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	23	10	10
disruptive	5	35	18	52
missense	5	33	16	46

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	34	7	17
disruptive	19	83	31	125
missense	14	65	26	64

PlasmoDB Total SNPs: 136

Non-coding: 112 | Synonymous: 14 | Nonsynonymous: 9 | Stop Codon: 1

Protein Information

Protein Length: 287 | Molecular Weight (kDa): 34.618

UniProt ID(s): Q8I477

PDB ID(s): None

Isoelectric Point: 9.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A