PF3D7_0502500

Genome location: Pf3D7_05_v3:114,149..115,933(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKFISIKYLSLFFLSILFVHS

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0502500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -2.943 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I475

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533576

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	26	16	29
disruptive	18	74	44	95
missense	11	59	40	82

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	53	19	47
disruptive	34	180	89	182
missense	22	130	64	108

PlasmoDB Total SNPs: 48

Non-coding: 0 | Synonymous: 32 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 594 | Molecular Weight (kDa): 71.672

UniProt ID(s): Q8I475

PDB ID(s): None

Isoelectric Point: 8.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A