PF3D7_0502600

Genome location: Pf3D7_05_v3:116,198..120,058(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.04	0.98
Trophozoite	no data	0.16	0.90
Schizont	no data	0.08	0.95
Gametocyte	no data	0.48	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0502600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.944 | MFS: -2.951 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1102300)

Relative Growth Rate: 0.91 ± 0.14
Confidence: 5.38

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1102300)

Modification: Disrupted | RMgm-2926

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4C1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532906

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	53	29	65
disruptive	22	155	81	163
missense	18	145	77	144

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	99	41	61
disruptive	74	316	114	254
missense	52	268	89	193

PlasmoDB Total SNPs: 177

Non-coding: 105 | Synonymous: 44 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 889 | Molecular Weight (kDa): 107.744

UniProt ID(s): C0H4C1

PDB ID(s): None

Isoelectric Point: 10.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A