PF3D7_0502800

Genome location: Pf3D7_05_v3:122,377..123,300(+)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0001671	ATPase activator activity
Function	GO:0008198	ferrous iron binding
Process	GO:0032781	positive regulation of ATP-dependent activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.02	0.99
Schizont	not expressed	0.00	1.00
Gametocyte	expressed	0.02	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0502800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.423 | MFS: -2.99 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I473

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104505

Most Similar Human Ortholog: E9PRW3

TM-align score: 0.55 | RMSD: 1.66

Seq Identity: 0.23 | Length: 34 / 137

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000170946	DnaJ heat shock protein family (Hsp40) member C24

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 14

Non-coding: 7 | Synonymous: 2 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 137 | Molecular Weight (kDa): 16.408

UniProt ID(s): Q8I473

PDB ID(s): None

Isoelectric Point: 5.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR007872	DPH-type metal-binding domain
InterPro	IPR036671	DPH-type metal-binding domain superfamily
InterPro	IPR036869	Chaperone J-domain superfamily
InterPro	IPR042978	DnaJ homolog subfamily C member 24
PFam	PF00226	DnaJ domain
PFam	PF05207	DPH-type metal-binding domain
Superfamily	SSF144217	DPH-type metal-binding domain superfamily
Superfamily	SSF46565	Chaperone J-domain superfamily