PF3D7_0503000

Genome location: Pf3D7_05_v3:125,012..126,861(+)

Genome classification: Core

Function and Localization

Product Description: 50S ribosomal protein L28, apicoplast, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast
Component	GO:0015934	large ribosomal subunit
Component	GO:0005762	mitochondrial large ribosomal subunit
Function	GO:0003735	structural constituent of ribosome
Process	GO:0006412	translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.20	0.90
Trophozoite	expressed	0.48	0.72
Schizont	expressed	0.66	0.65
Gametocyte	expressed	1.20	0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0503000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.854 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4C3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105372

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	16	5	17
disruptive	1	20	16	37
missense	1	20	16	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	23	10	24
disruptive	8	59	28	63
missense	4	51	21	44

PlasmoDB Total SNPs: 133

Non-coding: 115 | Synonymous: 14 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 262 | Molecular Weight (kDa): 31.225

UniProt ID(s): C0H4C3

PDB ID(s): None

Isoelectric Point: 11.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001383	Ribosomal protein L28
InterPro	IPR026569	Ribosomal protein L28/L24
InterPro	IPR034704	L28p-like
PFam	PF00830	Ribosomal protein L28/L24
Superfamily	SSF143800	L28p-like