About Gene List

PF3D7_0503200 (CDC6)

Genome location: Pf3D7_05_v3:130,209..133,825(+)

Genome classification: Core

Function and Localization

Product Description: cell division control protein 6, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion
Component GO:0005664 nuclear origin of replication recognition complex
Function GO:0003688 DNA replication origin binding
Process GO:0006270 DNA replication initiation
Process GO:0033314 mitotic DNA replication checkpoint signaling
Process GO:0000278 mitotic cell cycle

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite expressed 0.42 0.75
Schizont possibly expressed 0.41 0.75
Gametocyte expressed 0.98 0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0503200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -3.285 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1102900)

  • Relative Growth Rate: 0.23 ± 0.18
  • Confidence: 4.85

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I469

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.50) with 5UJ7 (Global RMSD=7.58)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532766

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 15 42 25 63
disruptive 47 118 70 143
missense 25 96 59 117

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 21 100 33 58
disruptive 76 236 135 265
missense 36 182 108 174

PlasmoDB Total SNPs: 231

Non-coding: 116 | Synonymous: 58 | Nonsynonymous: 57 | Stop Codon: 0

Protein Information

Protein Length: 979 | Molecular Weight (kDa): 115.088

UniProt ID(s): Q8I469

PDB ID(s): None

Isoelectric Point: 8.33

Protein Domain Annotations:

Source Family ID Description
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFam PF00004 ATPase, AAA-type, core
Superfamily SSF52540 P-loop containing nucleoside triphosphate hydrolase

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21