PF3D7_0503900

Genome location: Pf3D7_05_v3:153,455..156,762(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.21	0.88
Schizont	not expressed	0.02	0.98
Gametocyte	not expressed	0.10	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0503900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.66 | MFS: -3.021 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1103500)

Relative Growth Rate: 0.09 ± 0.04
Confidence: 8.03

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1103500)

Modification: Tagged | RMgm-4969

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I462

"Best" AlphaFill ligand hit: CLQ (n4-(7-chloro-quinolin-4-yl)-n1,n1-diethyl-pentane-1,4-diamine, Local RMSD=0.13) with 7DI7 (Global RMSD=28.83)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160183

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	27	17	43
disruptive	32	69	39	101
missense	13	38	24	70

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	56	29	42
disruptive	53	172	88	163
missense	19	100	50	91

PlasmoDB Total SNPs: 197

Non-coding: 104 | Synonymous: 56 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 662 | Molecular Weight (kDa): 78.418

UniProt ID(s): Q8I462

PDB ID(s): None

Isoelectric Point: 9.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF51197	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21