PF3D7_0504100

Genome location: Pf3D7_05_v3:165,089..166,846(-)

Genome classification: Core

Function and Localization

Product Description: AN1-type zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0008270	zinc ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.03	0.98
Schizont	possibly expressed	0.09	0.94
Gametocyte	expressed	0.04	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0504100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.229 | MFS: -2.856 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I460

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=11.44) with 4O30 (Global RMSD=25.20)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102690

Most Similar Human Ortholog: C9J1R6

TM-align score: 0.81 | RMSD: 1.57

Seq Identity: 0.38 | Length: 50 / 147

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000158552	zinc finger AN1-type containing 2B

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	9	5
disruptive	2	8	6	21
missense	1	8	5	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	13	9	8
disruptive	5	24	13	24
missense	2	21	10	13

PlasmoDB Total SNPs: 122

Non-coding: 116 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 147 | Molecular Weight (kDa): 17.615

UniProt ID(s): Q8I460

PDB ID(s): None

Isoelectric Point: 8.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000058	Zinc finger, AN1-type
InterPro	IPR035896	AN1-like Zinc finger
PFam	PF01428	Zinc finger, AN1-type
Superfamily	SSF118310	AN1-like Zinc finger