PF3D7_0504300

Genome location: Pf3D7_05_v3:169,539..170,888(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.10	0.94
Schizont	not expressed	0.03	0.98
Gametocyte	possibly expressed	0.39	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0504300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.965 | MFS: -2.539 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1103900)

Relative Growth Rate: 1.03 ± 0.08
Confidence: 6.40

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1103900)

Modification: Disrupted | RMgm-2937

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I458

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533053

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	6	4	8
disruptive	3	15	24	46
missense	3	15	24	41

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	12	6	16
disruptive	6	65	31	48
missense	5	53	30	32

PlasmoDB Total SNPs: 69

Non-coding: 58 | Synonymous: 6 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 224 | Molecular Weight (kDa): 27.474

UniProt ID(s): Q8I458

PDB ID(s): None

Isoelectric Point: 6.98

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A