About Gene List

PF3D7_0504500

Genome location: Pf3D7_05_v3:174,882..176,765(+)

Genome classification: Core

Function and Localization

Product Description: MOLO1 domain-containing protein, putative

SignalP Peptide: MKLFLSVICSFVLFFHKLSIC

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044312 crystalloid

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.00 1.00
Trophozoite expressed 0.00 1.00
Schizont expressed 0.00 1.00
Gametocyte expressed 0.65 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0504500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 2.161 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1104100)

  • Relative Growth Rate: 0.94 ± 0.08
  • Confidence: 6.56

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1104100)

Modification: Tagged | RMgm-4865

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I456

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146132

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 16 7 11
disruptive 3 16 8 22
missense 3 16 8 18

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 23 14 12
disruptive 4 34 18 20
missense 3 32 14 18

PlasmoDB Total SNPs: 119

Non-coding: 99 | Synonymous: 15 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 275 | Molecular Weight (kDa): 31.89

UniProt ID(s): Q8I456

PDB ID(s): None

Isoelectric Point: 6.16

Protein Domain Annotations:

Source Family ID Description
InterPro IPR033438 Modulator of levamisole receptor-1
PFam PF17175 Modulator of levamisole receptor-1
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
32736136 Plasmodium berghei LAPs form an extended protein complex that facilitatescrystalloid targeting and biogenesis. Tremp AZ, Saeed S, ..., Dessens JT 10.1016/j.jprot.2020.103925