PF3D7_0504700 (CEP120)

Genome location: Pf3D7_05_v3:179,898..187,747(+)

Genome classification: Core

Function and Localization

Product Description: centrosomal protein CEP120, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005813	centrosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.96
Trophozoite	not expressed	0.33	0.81
Schizont	not expressed	0.09	0.94
Gametocyte	not expressed	1.30	0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0504700

Resistome Missense Mutations: I1495T

Resistome Compounds with Missense Mutations: MMV019662

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.667 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1104300)

Modification: Disrupted | RMgm-2941

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I455

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532366

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	72	32	97
disruptive	94	282	137	315
missense	60	206	111	230

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	46	124	58	103
disruptive	171	547	194	422
missense	99	379	137	287

PlasmoDB Total SNPs: 1036

Non-coding: 89 | Synonymous: 669 | Nonsynonymous: 278 | Stop Codon: 0

Protein Information

Protein Length: 2349 | Molecular Weight (kDa): 291.039

UniProt ID(s): Q8I455

PDB ID(s): None

Isoelectric Point: 9.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104