About Gene List

PF3D7_0504800

Genome location: Pf3D7_05_v3:187,586..205,020(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005730 nucleolus
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.25 0.89
Trophozoite possibly expressed 1.68 0.35
Schizont expressed 1.56 0.46
Gametocyte possibly expressed 1.57 0.30

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0504800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.985 | MFS: -2.72 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 45 236 134 305
disruptive 264 798 460 1002
missense 156 644 390 843

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 80 458 235 335
disruptive 458 1632 704 1351
missense 249 1261 576 972

PlasmoDB Total SNPs: 715

Non-coding: 32 | Synonymous: 417 | Nonsynonymous: 266 | Stop Codon: 0

Protein Information

Protein Length: 5639 | Molecular Weight (kDa): 672.022

UniProt ID(s): C0H4C4

PDB ID(s): None

Isoelectric Point: 7.5

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011004 Trimeric LpxA-like superfamily
PFam N/A N/A
Superfamily SSF51161 Trimeric LpxA-like superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108