PF3D7_0505000

Genome location: Pf3D7_05_v3:208,676..219,273(-)

Genome classification: Core

Function and Localization

Product Description: MMS19-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005743	mitochondrial inner membrane
Process	GO:0042407	cristae formation
Process	GO:0008053	mitochondrial fusion
Process	GO:0034982	mitochondrial protein processing
Process	GO:0065003	protein-containing complex assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.64	0.71
Trophozoite	expressed	0.67	0.65
Schizont	expressed	0.19	0.89
Gametocyte	expressed	0.70	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0505000

Resistome Missense Mutations: K1414N

Resistome Compounds with Missense Mutations: AN13762, AN13956

Resistome # Samples with Disruptive Mutations: 11 (8 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.179 | MFS: -2.825 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
P0C6X4	Replicase polyprotein 1ab		OrthoMCL BLAST	cmdc.202100576, 6bUS9975885, Compound 6US9975885, Compound 13US9975885, Compound 14...

Orthology Information

Ortholog Group (OrthoMCL): OG6_105151

No human ortholog(s)

Protein Information

Protein Length: 2975 | Molecular Weight (kDa): 355.181

UniProt ID(s): C0H4C6

PDB ID(s): None

Isoelectric Point: 4.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029240	MMS19, N-terminal
PFam	PF14500	MMS19, N-terminal
Superfamily	N/A	N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	40	107	94	161
disruptive	268	521	243	544
missense	139	332	174	386

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	55	249	124	193
disruptive	428	945	348	824
missense	217	601	262	520

PlasmoDB Total SNPs: 784

Non-coding: 106 | Synonymous: 280 | Nonsynonymous: 393 | Stop Codon: 5

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104