Product Description: actin-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0035267 | NuA4 histone acetyltransferase complex |
| Component | GO:0016514 | SWI/SNF complex |
| Component | GO:0015629 | actin cytoskeleton |
| Component | GO:0005634 | nucleus |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0005200 | structural constituent of cytoskeleton |
| Process | GO:0043044 | ATP-dependent chromatin remodeling |
| Process | GO:0007010 | cytoskeleton organization |
| Process | GO:0043967 | histone H4 acetylation |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.08 | 0.95 |
| Trophozoite | not expressed | 0.19 | 0.87 |
| Schizont | not expressed | 0.18 | 0.88 |
| Gametocyte | not expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0505200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.848 | MFS: -2.884 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1104800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1104800)
Modification: Disrupted | RMgm-2943
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I450
"Best" AlphaFill ligand hit: LAB (latrunculin b, Local RMSD=0.02) with 6NBW (Global RMSD=4.51)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 34 | 14 | 29 |
| disruptive | 15 | 72 | 21 | 95 |
| missense | 11 | 58 | 20 | 80 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 62 | 20 | 30 |
| disruptive | 25 | 128 | 78 | 154 |
| missense | 16 | 102 | 66 | 109 |
PlasmoDB Total SNPs: 120
Non-coding: 58 | Synonymous: 38 | Nonsynonymous: 24 | Stop Codon: 0
Protein Length: 565 | Molecular Weight (kDa): 65.868
UniProt ID(s): Q8I450
PDB ID(s): None
Isoelectric Point: 4.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004000 | Actin family |
| InterPro | IPR043129 | ATPase, nucleotide binding domain |
| PFam | PF00022 | Actin family |
| Superfamily | SSF53067 | ATPase, nucleotide binding domain |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |