PF3D7_0505300

Genome location: Pf3D7_05_v3:233,139..235,836(+)

Genome classification: Core

Function and Localization

Product Description: UDP-N-acetylglucosamine transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005794	Golgi apparatus
Component	GO:0030173	integral component of Golgi membrane
Function	GO:0015136	sialic acid transmembrane transporter activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	possibly expressed	0.12	0.92
Schizont	expressed	0.07	0.95
Gametocyte	not expressed	0.03	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0505300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.984 | MFS: -1.055 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1104900)

Relative Growth Rate: 0.96 ± 0.09
Confidence: 6.30

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1104900)

Modification: Disrupted | RMgm-2944

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I449

"Best" AlphaFill ligand hit: C5P (cytidine-5'-monophosphate, Local RMSD=2.27) with 6I1R (Global RMSD=5.21)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100998

Most Similar Human Ortholog: A0A1W2PRT7

TM-align score: 0.78 | RMSD: 3.24

Seq Identity: 0.23 | Length: 258 / 611

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000102100	solute carrier family 35 member A2
ENSG00000117620	solute carrier family 35 member A3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	19	18	27
disruptive	10	72	40	81
missense	8	63	32	64

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	42	31	33
disruptive	35	175	69	163
missense	20	128	54	100

PlasmoDB Total SNPs: 167

Non-coding: 91 | Synonymous: 57 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 611 | Molecular Weight (kDa): 74.041

UniProt ID(s): Q8I449

PDB ID(s): None

Isoelectric Point: 10.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007271	Nucleotide-sugar transporter
PFam	PF04142	Nucleotide-sugar transporter
Superfamily	SSF103481	N/A