Product Description: DNA mismatch repair protein MSH6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0032301 | MutSalpha complex |
Component | GO:0032300 | mismatch repair complex |
Component | GO:0005634 | nucleus |
Function | GO:0008094 | ATP-dependent activity, acting on DNA |
Function | GO:0003684 | damaged DNA binding |
Function | GO:0000400 | four-way junction DNA binding |
Function | GO:0030983 | mismatched DNA binding |
Process | GO:0006281 | DNA repair |
Process | GO:0036297 | interstrand cross-link repair |
Process | GO:0043570 | maintenance of DNA repeat elements |
Process | GO:0000710 | meiotic mismatch repair |
Process | GO:0006298 | mismatch repair |
Process | GO:0045910 | negative regulation of DNA recombination |
Process | GO:0006290 | pyrimidine dimer repair |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.13 | 0.94 |
Trophozoite | expressed | 0.82 | 0.56 |
Schizont | expressed | 0.31 | 0.81 |
Gametocyte | expressed | 0.47 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0505500
Resistome Missense Mutations: P462R
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.696 | MFS: -2.407 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1105100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I447
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.17) with 2WTU (Global RMSD=5.87)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100652
Most Similar Human Ortholog: A0A494C0M1
TM-align score: 0.70 | RMSD: 4.50
Seq Identity: 0.30 | Length: 979 / 1350
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000116062 | mutS homolog 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 12 | 74 | 48 | 76 |
disruptive | 21 | 69 | 53 | 100 |
missense | 16 | 61 | 48 | 82 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 19 | 151 | 53 | 94 |
disruptive | 42 | 160 | 89 | 198 |
missense | 32 | 121 | 74 | 135 |
PlasmoDB Total SNPs: 157
Non-coding: 102 | Synonymous: 31 | Nonsynonymous: 23 | Stop Codon: 1
Protein Length: 1350 | Molecular Weight (kDa): 156.44
UniProt ID(s): Q8I447
PDB ID(s): None
Isoelectric Point: 6.35
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000432 | DNA mismatch repair protein MutS, C-terminal |
InterPro | IPR007695 | DNA mismatch repair protein MutS-like, N-terminal |
InterPro | IPR007696 | DNA mismatch repair protein MutS, core |
InterPro | IPR007861 | DNA mismatch repair protein MutS, clamp |
InterPro | IPR016151 | DNA mismatch repair protein MutS, N-terminal |
InterPro | IPR017261 | DNA mismatch repair protein MutS/MSH |
InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
InterPro | IPR036187 | DNA mismatch repair protein MutS, core domain superfamily |
InterPro | IPR036678 | MutS, connector domain superfamily |
PFam | PF00488 | DNA mismatch repair protein MutS, C-terminal |
PFam | PF01624 | DNA mismatch repair protein MutS-like, N-terminal |
PFam | PF05190 | DNA mismatch repair protein MutS, clamp |
PFam | PF05192 | DNA mismatch repair protein MutS, core |
Superfamily | SSF48334 | DNA mismatch repair protein MutS, core domain superfamily |
Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
Superfamily | SSF53150 | MutS, connector domain superfamily |
Superfamily | SSF55271 | DNA mismatch repair protein MutS, N-terminal |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
38315739 | Nonhomologous tails direct heteroduplex rejection and mismatch correction duringsingle-strand annealing in Saccharomyces cerevisiae | Sapede E, Sugawara N, ..., Haber JE | 10.1371/journal.pgen.1010527 |