Product Description: BCNT domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.27 | 0.87 |
Trophozoite | not expressed | 0.59 | 0.67 |
Schizont | not expressed | 0.16 | 0.90 |
Gametocyte | not expressed | 0.52 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0505600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.252 | MFS: -2.721 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1105200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I446
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 2 | 13 | 6 | 18 |
disruptive | 11 | 56 | 36 | 57 |
missense | 6 | 31 | 27 | 40 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 26 | 7 | 22 |
disruptive | 39 | 124 | 58 | 106 |
missense | 18 | 75 | 38 | 62 |
PlasmoDB Total SNPs: 70
Non-coding: 37 | Synonymous: 18 | Nonsynonymous: 15 | Stop Codon: 0
Protein Length: 333 | Molecular Weight (kDa): 40.203
UniProt ID(s): Q8I446
PDB ID(s): None
Isoelectric Point: 7.26
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR011421 | BCNT-C domain |
PFam | PF07572 | BCNT-C domain |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |