About Gene List

PF3D7_0505600

Genome location: Pf3D7_05_v3:245,653..247,093(+)

Genome classification: Core

Function and Localization

Product Description: BCNT domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.27 0.87
Trophozoite not expressed 0.59 0.67
Schizont not expressed 0.16 0.90
Gametocyte not expressed 0.52 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0505600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.252 | MFS: -2.721 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1105200)

  • Relative Growth Rate: 0.03 ± 0.04
  • Confidence: 7.62

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I446

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126422

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 13 6 18
disruptive 11 56 36 57
missense 6 31 27 40

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 26 7 22
disruptive 39 124 58 106
missense 18 75 38 62

PlasmoDB Total SNPs: 70

Non-coding: 37 | Synonymous: 18 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 333 | Molecular Weight (kDa): 40.203

UniProt ID(s): Q8I446

PDB ID(s): None

Isoelectric Point: 7.26

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011421 BCNT-C domain
PFam PF07572 BCNT-C domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108