About Gene List

PF3D7_0505700

Genome location: Pf3D7_05_v3:247,142..250,905(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: MKLTCYCIMFLFIHIIKYVSC

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.31 0.85
Trophozoite possibly expressed 0.83 0.56
Schizont possibly expressed 0.28 0.83
Gametocyte not expressed 0.61 0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0505700

Resistome Missense Mutations: N803T

Resistome Compounds with Missense Mutations: AN13762, AN13956

Resistome # Samples with Disruptive Mutations: 9 (9 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.421 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1105300)

Modification: Tagged | RMgm-4888

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I445

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_189397

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 32 22 47
disruptive 68 133 82 186
missense 33 106 61 135

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 20 70 33 54
disruptive 95 314 100 229
missense 48 227 72 148

PlasmoDB Total SNPs: 361

Non-coding: 144 | Synonymous: 131 | Nonsynonymous: 85 | Stop Codon: 1

Protein Information

Protein Length: 924 | Molecular Weight (kDa): 112.7

UniProt ID(s): Q8I445

PDB ID(s): None

Isoelectric Point: 6.32

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895