Product Description: small ubiquitin-related modifier
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Function | GO:0031386 | protein tag |
| Function | GO:0044389 | ubiquitin-like protein ligase binding |
| Process | GO:0019941 | modification-dependent protein catabolic process |
| Process | GO:0016925 | protein sumoylation |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.11 | 0.94 |
| Trophozoite | expressed | 0.30 | 0.81 |
| Schizont | expressed | 0.09 | 0.93 |
| Gametocyte | expressed | 0.12 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0505800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.143 | MFS: -2.803 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1105400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I444
"Best" AlphaFill ligand hit: FMN (flavin mononucleotide, Local RMSD=0.24) with 1Q45 (Global RMSD=15.35)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P61956 | Sentrin-specific protease/Small ubiquitin-related modifier 2 | Homo sapiens | OMA, OrthoDB, OrthoMCL BLAST | SPI-01SPI-02SPI-03SPI-04... |
| P63165 | Small ubiquitin-related modifier 1 | Homo sapiens | OrthoDB, OrthoMCL BLAST | SPI-01SPI-01SPI-02SPI-02... |
Ortholog Group (OrthoMCL): OG6_100654
Most Similar Human Ortholog: J3KRH1
TM-align score: 0.81 | RMSD: 1.39
Seq Identity: 0.51 | Length: 49 / 100
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000116030 | small ubiquitin like modifier 1 |
| ENSG00000188612 | small ubiquitin like modifier 2 |
Protein Length: 100 | Molecular Weight (kDa): 11.06
UniProt ID(s): Q8I444
PDB ID(s): None
Isoelectric Point: 4.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000626 | Ubiquitin-like domain |
| InterPro | IPR022617 | Rad60/SUMO-like domain |
| InterPro | IPR029071 | Ubiquitin-like domain superfamily |
| PFam | PF11976 | Rad60/SUMO-like domain |
| Superfamily | SSF54236 | Ubiquitin-like domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 191
Non-coding: 188 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18547337 | Identification of a novel post-translational modification in Plasmodiumfalciparum: protein sumoylation in different cellular compartments. | Issar N, Roux E, Mattei D, Scherf A | 10.1111/j.1462-5822.2008.01183.x |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 23943616 | Identification of biochemically distinct properties of the smallubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum. | Reiter K, Mukhopadhyay D, ..., Matunis MJ | 10.1074/jbc.M113.498410 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 35331687 | Implications of critical node-dependent unidirectional cross-talk of PlasmodiumSUMO pathway proteins. | Singh JS, Sajeev T K, ..., Mishra RK | 10.1016/j.bpj.2022.03.022 |