Product Description: mediator of RNA polymerase II transcription subunit 11, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0016592 | mediator complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | possibly expressed | 0.13 | 0.94 |
Trophozoite | expressed | 0.52 | 0.69 |
Schizont | expressed | 0.06 | 0.96 |
Gametocyte | expressed | 0.36 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0505900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.808 | MFS: -2.634 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4C7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 0 | 0 | 0 |
disruptive | 0 | 1 | 0 | 0 |
missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 0 | 0 | 0 |
disruptive | 1 | 1 | 3 | 1 |
missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 187
Non-coding: 181 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 126 | Molecular Weight (kDa): 14.828
UniProt ID(s): C0H4C7
PDB ID(s): None
Isoelectric Point: 8.45
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | SSF46579 | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
9812975 | Identification of new mediator subunits in the RNA polymerase II holoenzyme fromSaccharomyces cerevisiae | Gustafsson CM, Myers LC, ..., Kornberg RD | 10.1074/jbc.273.47.30851 |
12584197 | Identification of mammalian Mediator subunits with similarities to yeast Mediatorsubunits Srb5, Srb6, Med11, and Rox3 | Sato S, Tomomori-Sato C, ..., Conaway JW | 10.1074/jbc.C300054200 |
9891034 | Activator-specific requirement of yeast mediator proteins for RNA polymerase IItranscriptional activation | Han SJ, Lee YC, ..., Kim YJ | 10.1128/MCB.19.2.979 |