About Gene List

PF3D7_0505900 (MED11)

Genome location: Pf3D7_05_v3:254,058..256,048(-)

Genome classification: Core

Function and Localization

Product Description: mediator of RNA polymerase II transcription subunit 11, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016592 mediator complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.13 0.94
Trophozoite expressed 0.52 0.69
Schizont expressed 0.06 0.96
Gametocyte expressed 0.36 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0505900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.808 | MFS: -2.634 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4C7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533136

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 1 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 1 1 3 1
missense 0 0 0 0

PlasmoDB Total SNPs: 187

Non-coding: 181 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 126 | Molecular Weight (kDa): 14.828

UniProt ID(s): C0H4C7

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF46579 N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
9812975 Identification of new mediator subunits in the RNA polymerase II holoenzyme fromSaccharomyces cerevisiae Gustafsson CM, Myers LC, ..., Kornberg RD 10.1074/jbc.273.47.30851
12584197 Identification of mammalian Mediator subunits with similarities to yeast Mediatorsubunits Srb5, Srb6, Med11, and Rox3 Sato S, Tomomori-Sato C, ..., Conaway JW 10.1074/jbc.C300054200
9891034 Activator-specific requirement of yeast mediator proteins for RNA polymerase IItranscriptional activation Han SJ, Lee YC, ..., Kim YJ 10.1128/MCB.19.2.979