PF3D7_0506000

Genome location: Pf3D7_05_v3:256,063..257,694(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.26	0.87
Trophozoite	possibly expressed	0.62	0.65
Schizont	possibly expressed	0.09	0.94
Gametocyte	possibly expressed	0.46	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0506000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.15 | MFS: -3.387 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I442

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533500

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	5	10	9
disruptive	4	22	16	40
missense	4	21	14	35

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	15	10	12
disruptive	14	59	31	51
missense	10	46	25	31

PlasmoDB Total SNPs: 115

Non-coding: 113 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 246 | Molecular Weight (kDa): 29.643

UniProt ID(s): Q8I442

PDB ID(s): None

Isoelectric Point: 10.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A