PF3D7_0506100

Genome location: Pf3D7_05_v3:256,330..259,207(-)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal subunit protein L24, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0022625	cytosolic large ribosomal subunit
Component	GO:0015934	large ribosomal subunit
Function	GO:0003723	RNA binding
Function	GO:0003735	structural constituent of ribosome
Process	GO:1902626	assembly of large subunit precursor of preribosome
Process	GO:0000027	ribosomal large subunit assembly
Process	GO:0006412	translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.73	0.65
Trophozoite	expressed	0.70	0.61
Schizont	expressed	0.14	0.91
Gametocyte	expressed	0.64	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0506100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.366 | MFS: -3.407 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I441

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=2.88) with 6JWQ (Global RMSD=25.17)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101340

Most Similar Human Ortholog: H3BPF2

TM-align score: 0.84 | RMSD: 2.22

Seq Identity: 0.58 | Length: 79 / 204

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000137876	ribosomal L24 domain containing 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	12	9	12
disruptive	1	15	10	19
missense	1	15	10	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	24	9	12
disruptive	2	40	15	55
missense	2	32	13	31

PlasmoDB Total SNPs: 67

Non-coding: 59 | Synonymous: 2 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 204 | Molecular Weight (kDa): 24.872

UniProt ID(s): Q8I441

PDB ID(s): None

Isoelectric Point: 10.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000988	Ribosomal protein L24e-related
InterPro	IPR011017	TRASH domain
InterPro	IPR023442	Ribosomal protein L24e, conserved site
PFam	PF01246	Ribosomal protein L24e-related
Superfamily	SSF57716	N/A