Product Description: TATA-box-binding protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0005669 | transcription factor TFIID complex |
| Function | GO:0016251 | RNA polymerase II general transcription initiation factor activity |
| Process | GO:0006352 | DNA-templated transcription, initiation |
| Process | GO:0006366 | transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.23 | 0.88 |
| Trophozoite | not expressed | 0.16 | 0.90 |
| Schizont | not expressed | 0.06 | 0.96 |
| Gametocyte | not expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0506200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.175 | MFS: -2.784 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_1106900)
Modification: Tagged | RMgm-1511
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I440
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100597
Most Similar Human Ortholog: Q6SJ96
TM-align score: 0.57 | RMSD: 2.60
Seq Identity: 0.34 | Length: 203 / 327
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112592 | TATA-box binding protein |
| ENSG00000182521 | TATA-box binding protein like 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 20 | 9 | 18 |
| disruptive | 19 | 42 | 22 | 52 |
| missense | 10 | 26 | 12 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 34 | 11 | 25 |
| disruptive | 24 | 86 | 28 | 95 |
| missense | 13 | 52 | 22 | 52 |
PlasmoDB Total SNPs: 105
Non-coding: 26 | Synonymous: 48 | Nonsynonymous: 31 | Stop Codon: 0
Protein Length: 327 | Molecular Weight (kDa): 38.158
UniProt ID(s): P32086, Q549B4, Q8I440
PDB ID(s): None
Isoelectric Point: 6.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000814 | TATA-box binding protein |
| InterPro | IPR030491 | TATA-box binding protein, conserved site |
| InterPro | IPR033710 | TATA-box binding protein, eukaryotic |
| PFam | PF00352 | TATA-box binding protein |
| Superfamily | SSF55945 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15760658 | Recombinant and native Plasmodium falciparum TATA-binding-protein binds to aspecific TATA box element in promoter regions. | Ruvalcaba-Salazar OK, del Carmen Ramirez-Estudillo M, ..., Hernandez-Rivas R | 10.1016/j.molbiopara.2005.01.002 |
| 18951895 | Plasmodium falciparum: Preinitiation complex occupancy of active and inactivepromoters during erythrocytic stage. | Gopalakrishnan AM, Nyindodo LA, Ross Fergus M, Lopez-Estrano C | 10.1016/j.exppara.2008.09.016 |
| 27434123 | Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates forCombination Vaccines with Circumsporozoite Protein. | Speake C, Pichugin A, ..., Duffy PE | 10.1371/journal.pone.0159449 |
| 38397602 | Efficient and Selective Extraction of Rhamnogalacturonan-I-Enriched PecticPolysaccharides from Tartary Buckwheat Leaves Using Deep-Eutectic-Solvent-BasedTechniques | Wu DT, Lei J, ..., Zou L | 10.3390/foods13040625 |