PF3D7_0506300

Genome location: Pf3D7_05_v3:260,639..262,284(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003905	alkylbase DNA N-glycosylase activity
Process	GO:0006284	base-excision repair

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.14	0.93
Trophozoite	expressed	0.67	0.63
Schizont	expressed	0.12	0.93
Gametocyte	possibly expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0506300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.165 | MFS: -3.308 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I439

"Best" AlphaFill ligand hit: U5P (uridine-5'-monophosphate, Local RMSD=0.58) with 6DSR (Global RMSD=17.35)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532575

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	15	13	29
disruptive	25	47	27	64
missense	12	35	19	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	28	23	26
disruptive	37	91	47	89
missense	19	70	32	58

PlasmoDB Total SNPs: 82

Non-coding: 28 | Synonymous: 28 | Nonsynonymous: 25 | Stop Codon: 1

Protein Information

Protein Length: 407 | Molecular Weight (kDa): 48.549

UniProt ID(s): Q8I439

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003180	Methylpurine-DNA glycosylase
InterPro	IPR011004	Trimeric LpxA-like superfamily
PFam	N/A	N/A
Superfamily	SSF51161	Trimeric LpxA-like superfamily