PF3D7_0506400

Genome location: Pf3D7_05_v3:262,672..263,925(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.25	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0506400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.126 | MFS: -3.113 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K846

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533397

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	9	5	8
disruptive	1	8	2	16
missense	1	8	2	14

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	15	7	5
disruptive	2	20	11	25
missense	1	14	10	20

PlasmoDB Total SNPs: 73

Non-coding: 71 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 116 | Molecular Weight (kDa): 14.058

UniProt ID(s): A0A5K1K846

PDB ID(s): None

Isoelectric Point: 8.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A