PF3D7_0506500

Genome location: Pf3D7_05_v3:264,456..278,345(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.48	0.79
Trophozoite	expressed	1.19	0.43
Schizont	expressed	1.00	0.49
Gametocyte	possibly expressed	2.02	0.19

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0506500

Resistome Missense Mutations: Q1304P, E1307Q, P1310Q

Resistome Compounds with Missense Mutations: AN13762, AN13956

Resistome # Samples with Disruptive Mutations: 8 (8 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.284 | #Insertions: 11

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1446500)

Relative Growth Rate: 0.05 ± 0.05
Confidence: 7.48

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110457

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	31	130	92	188
disruptive	250	585	347	783
missense	164	433	297	627

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	46	283	150	242
disruptive	429	1289	547	1218
missense	235	982	412	714

PlasmoDB Total SNPs: 878

Non-coding: 187 | Synonymous: 338 | Nonsynonymous: 351 | Stop Codon: 2

Protein Information

Protein Length: 3980 | Molecular Weight (kDa): 469.873

UniProt ID(s): C0H4C9

PDB ID(s): None

Isoelectric Point: 7.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A