PF3D7_0506700

Genome location: Pf3D7_05_v3:280,493..283,639(+)

Genome classification: Core

Function and Localization

Product Description: GTPase-activating protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005096	GTPase activator activity
Process	GO:0090630	activation of GTPase activity
Process	GO:0006886	intracellular protein transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.13	0.93
Trophozoite	expressed	0.49	0.71
Schizont	expressed	0.39	0.75
Gametocyte	expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0506700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -2.927 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1106300)

Relative Growth Rate: 0.59 ± 0.08
Confidence: 6.36

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1106300)

Modification: Disrupted | RMgm-2949

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I435

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101755

Most Similar Human Ortholog: M0R1Y1

TM-align score: 0.77 | RMSD: 1.94

Seq Identity: 0.18 | Length: 153 / 819

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000067208	ecotropic viral integration site 5
ENSG00000142459	ecotropic viral integration site 5 like

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	32	19	51
disruptive	107	142	55	139
missense	40	84	33	90

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	65	25	61
disruptive	145	209	98	176
missense	57	130	61	107

PlasmoDB Total SNPs: 235

Non-coding: 98 | Synonymous: 60 | Nonsynonymous: 77 | Stop Codon: 0

Protein Information

Protein Length: 819 | Molecular Weight (kDa): 97.192

UniProt ID(s): Q8I435

PDB ID(s): None

Isoelectric Point: 6.19

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000195	Rab-GTPase-TBC domain
InterPro	IPR035969	Rab-GTPase-TBC domain superfamily
PFam	PF00566	Rab-GTPase-TBC domain
Superfamily	SSF47923	Rab-GTPase-TBC domain superfamily