About Gene List

PF3D7_0506800 (TCF25)

Genome location: Pf3D7_05_v3:283,669..288,351(+)

Genome classification: Core

Function and Localization

Product Description: transcription factor 25, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.40 0.81
Trophozoite expressed 0.57 0.66
Schizont expressed 0.30 0.81
Gametocyte expressed 0.55 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0506800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.502 | #Insertions: 7

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1106400)

  • Relative Growth Rate: 0.91 ± 0.16
  • Confidence: 5.11

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1106400)

Modification: Disrupted | RMgm-2950

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I434

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102686

Most Similar Human Ortholog: Q9H384

TM-align score: 0.62 | RMSD: 4.25

Seq Identity: 0.19 | Length: 348 / 929

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000141002 transcription factor 25

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 42 17 55
disruptive 31 109 69 129
missense 23 99 65 116

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 77 43 58
disruptive 60 219 101 176
missense 41 189 93 130

PlasmoDB Total SNPs: 296

Non-coding: 210 | Synonymous: 52 | Nonsynonymous: 34 | Stop Codon: 0

Protein Information

Protein Length: 929 | Molecular Weight (kDa): 110.193

UniProt ID(s): Q8I434

PDB ID(s): None

Isoelectric Point: 7.97

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006994 TCF25/Rqc1
PFam PF04910 TCF25/Rqc1
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108