Product Description: 60S ribosomal protein L4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.34 | 0.21 |
| Trophozoite | expressed | 2.49 | 0.13 |
| Schizont | expressed | 0.70 | 0.62 |
| Gametocyte | expressed | 0.95 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0507100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.178 | MFS: -2.643 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I431
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100849
Most Similar Human Ortholog: H3BTP7
TM-align score: 0.95 | RMSD: 1.45
Seq Identity: 0.56 | Length: 170 / 411
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000174444 | ribosomal protein L4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 17 | 8 | 27 |
| disruptive | 1 | 11 | 7 | 43 |
| missense | 1 | 11 | 7 | 35 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 52 | 10 | 19 |
| disruptive | 4 | 31 | 23 | 87 |
| missense | 4 | 26 | 18 | 54 |
PlasmoDB Total SNPs: 148
Non-coding: 121 | Synonymous: 21 | Nonsynonymous: 5 | Stop Codon: 1
Protein Length: 411 | Molecular Weight (kDa): 46.211
UniProt ID(s): Q8I431
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002136 | Ribosomal protein L4/L1e |
| InterPro | IPR023574 | Ribosomal protein L4 domain superfamily |
| InterPro | IPR025755 | 60S ribosomal protein L4, C-terminal domain |
| PFam | PF00573 | Ribosomal protein L4/L1e |
| PFam | PF14374 | 60S ribosomal protein L4, C-terminal domain |
| Superfamily | SSF52166 | Ribosomal protein L4 domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |