Product Description: protein CAF40, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030014 | CCR4-NOT complex |
| Component | GO:0030015 | CCR4-NOT core complex |
| Component | GO:0000932 | P-body |
| Component | GO:0005634 | nucleus |
| Process | GO:0030154 | cell differentiation |
| Process | GO:0017148 | negative regulation of translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.30 | 0.85 |
| Trophozoite | expressed | 0.50 | 0.70 |
| Schizont | expressed | 0.35 | 0.76 |
| Gametocyte | expressed | 0.62 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0507600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3.091 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1107200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I427
"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.06) with 4CV5 (Global RMSD=1.11)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102178
Most Similar Human Ortholog: Q92600
TM-align score: 0.95 | RMSD: 1.56
Seq Identity: 0.62 | Length: 293 / 652
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000144580 | CCR4-NOT transcription complex subunit 9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 47 | 23 | 28 |
| disruptive | 39 | 56 | 33 | 103 |
| missense | 13 | 33 | 25 | 78 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 78 | 34 | 37 |
| disruptive | 53 | 126 | 78 | 174 |
| missense | 21 | 83 | 59 | 123 |
PlasmoDB Total SNPs: 223
Non-coding: 165 | Synonymous: 38 | Nonsynonymous: 20 | Stop Codon: 0
Protein Length: 652 | Molecular Weight (kDa): 73.424
UniProt ID(s): Q8I427
PDB ID(s): None
Isoelectric Point: 4.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007216 | CCR4-NOT transcription complex subunit 9 |
| InterPro | IPR016024 | Armadillo-type fold |
| PFam | PF04078 | N/A |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30703164 | Plasmodium male gametocyte development and transmission are critically regulatedby the two putative deadenylases of the CAF1/CCR4/NOT complex. | Hart KJ, Oberstaller J, ..., Lindner SE | 10.1371/journal.ppat.1007164 |
| 35052398 | Rapid Cis-Trans Coevolution Driven by a Novel Gene Retroposed from a EukaryoticConserved CCR4-NOT Component in Drosophila | Krinsky BH, Arthur RK, ..., Long M | 10.3390/genes13010057 |
| 30692204 | A conserved CAF40-binding motif in metazoan NOT4 mediates association with theCCR4-NOT complex | Keskeny C, Raisch T, ..., Izaurralde E | 10.1101/gad.320952.118 |
| 20504953 | Subunits of the Drosophila CCR4-NOT complex and their roles in mRNAdeadenylation | Temme C, Zhang L, ..., Wahle E | 10.1261/rna.2145110 |
| 15209511 | c-Myb protein interacts with Rcd-1, a component of the CCR4 transcriptionmediator complex | Haas M, Siegert M, ..., Wolfes H | 10.1021/bi035857y |
| 29255063 | Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of theCCR4-NOT complex to elicit repression of mRNA targets | Sgromo A, Raisch T, ..., Izaurralde E | 10.1261/rna.064584.117 |