PF3D7_0507800

Genome location: Pf3D7_05_v3:320,839..327,413(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.12	0.50
Trophozoite	expressed	1.25	0.39
Schizont	expressed	1.26	0.38
Gametocyte	expressed	0.87	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0507800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.716 | #Insertions: 2

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1107400)

Relative Growth Rate: 0.04 ± 0.04
Confidence: 7.66

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I425

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=1.11) with 6JWQ (Global RMSD=29.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_129543

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	47	37	83
disruptive	116	173	98	248
missense	61	123	75	193

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	123	62	83
disruptive	177	348	163	355
missense	96	246	127	222

PlasmoDB Total SNPs: 445

Non-coding: 164 | Synonymous: 124 | Nonsynonymous: 154 | Stop Codon: 3

Protein Information

Protein Length: 1527 | Molecular Weight (kDa): 177.426

UniProt ID(s): Q8I425

PDB ID(s): None

Isoelectric Point: 4.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104