Product Description: 6-cysteine protein P38
SignalP Peptide: MKRWSIITGIVIIFCILTCKG
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0046658 | anchored component of plasma membrane |
| Component | GO:0009986 | cell surface |
| Component | GO:0020009 | microneme |
| Function | GO:0046812 | host cell surface binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.09 | 0.94 |
| Schizont | expressed | 0.59 | 0.64 |
| Gametocyte | expressed | 0.15 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0508000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.938 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1107600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1107600)
Modification: Disrupted | RMgm-2958
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I423
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 11 | 7 | 13 |
| disruptive | 24 | 45 | 13 | 41 |
| missense | 24 | 45 | 11 | 35 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 16 | 10 | 20 |
| disruptive | 34 | 65 | 35 | 63 |
| missense | 34 | 57 | 30 | 44 |
PlasmoDB Total SNPs: 155
Non-coding: 128 | Synonymous: 6 | Nonsynonymous: 21 | Stop Codon: 0
Protein Length: 349 | Molecular Weight (kDa): 40.587
UniProt ID(s): A8QVQ2, A8QVQ3, A8QVQ4, A8QVQ5, A8QVQ7, A8QVR0, A8QVR1, A8QVR2, C5HE01, C5HE02, C5HE07, Q8I423, Q962H6
PDB ID(s): None
Isoelectric Point: 7.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010884 | 6-Cysteine (6-Cys) domain |
| PFam | PF07422 | 6-Cysteine (6-Cys) domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16203726 | Distinct protein classes including novel merozoite surface antigens in Raft-likemembranes of Plasmodium falciparum. | Sanders PR, Gilson PR, ..., Crabb BS | 10.1074/jbc.M509631200 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21569602 | Population genetic analysis of the Plasmodium falciparum 6-cys protein Pf38 inPapua New Guinea reveals domain-specific balancing selection. | Reeder JC, Wapling J, ..., Barry AE | 10.1186/1475-2875-10-126 |
| 27128092 | Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. | Swearingen KE, Lindner SE, ..., Sinnis P | 10.1371/journal.ppat.1005606 |
| 28202027 | A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stagemerozoites. | Paul G, Deshmukh A, ..., Malhotra P | 10.1186/s12936-017-1716-0 |
| 38423406 | Platycodon grandiflorus polysaccharide inhibits the inflammatory response of3D4/21_cells infected with PCV2 | Guo X, Zhao X, ..., Zhao X | 10.1016/j.micpath.2024.106592 |