PF3D7_0508100 (SET9)

Genome location: Pf3D7_05_v3:331,618..337,242(+)

Genome classification: Core

Function and Localization

Product Description: SET domain protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.1.1.43 (Transferred entry: 2.1.1.354)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.10	0.95
Trophozoite	expressed	0.45	0.78
Schizont	expressed	1.76	0.33
Gametocyte	expressed	0.79	0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0508100

Resistome Missense Mutations: D338Y

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.155 | MFS: -2.708 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1107700)

Relative Growth Rate: 0.00 ± 0.04
Confidence: 8.03

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I422

"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=0.03) with 3Q9N (Global RMSD=2.36)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.1.1.43	histone-lysine N-methyltransferase	BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_124161

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	25	79	49	95
disruptive	83	189	98	288
missense	35	121	75	222

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	146	62	97
disruptive	130	344	169	345
missense	52	240	123	242

PlasmoDB Total SNPs: 220

Non-coding: 17 | Synonymous: 126 | Nonsynonymous: 77 | Stop Codon: 0

Protein Information

Protein Length: 1674 | Molecular Weight (kDa): 195.628

UniProt ID(s): Q8I422

PDB ID(s): None

Isoelectric Point: 8.9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR036770	Ankyrin repeat-containing domain superfamily
PFam	PF12796	Ankyrin repeat-containing domain
Superfamily	SSF48403	Ankyrin repeat-containing domain superfamily
Superfamily	SSF82199

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108