About Gene List

PF3D7_0508300 (TPT)

Genome location: Pf3D7_05_v3:340,652..344,452(+)

Genome classification: Core

Function and Localization

Product Description: triose phosphate transporter

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005794 Golgi apparatus
Component GO:0020011 apicoplast
Component GO:0031355 integral component of plastid outer membrane
Component GO:0016020 membrane
Component GO:0009527 plastid outer membrane
Function GO:0005457 GDP-fucose transmembrane transporter activity
Function GO:0015297 antiporter activity
Function GO:0005338 nucleotide-sugar transmembrane transporter activity
Function GO:0022857 transmembrane transporter activity
Process GO:0046323 glucose import

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.10 0.95
Trophozoite expressed 0.46 0.72
Schizont expressed 0.04 0.97
Gametocyte possibly expressed 0.13 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0508300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.009 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1244600)

  • Relative Growth Rate: 0.14 ± 0.07
  • Confidence: 6.72

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I420

"Best" AlphaFill ligand hit: 3PG (3-phosphoglyceric acid, Local RMSD=0.40) with 5Y79 (Global RMSD=3.31)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101650

Most Similar Human Ortholog: Q96K37

TM-align score: 0.79 | RMSD: 2.70

Seq Identity: 0.22 | Length: 302 / 342

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000127526 solute carrier family 35 member E1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 276

Non-coding: 261 | Synonymous: 10 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 342 | Molecular Weight (kDa): 39.04

UniProt ID(s): Q8I420

PDB ID(s): None

Isoelectric Point: 9.82

Protein Domain Annotations:

Source Family ID Description
InterPro IPR004853 Sugar phosphate transporter domain
PFam PF03151 Sugar phosphate transporter domain
Superfamily SSF103481 N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16760253 Membrane transporters in the relict plastid of malaria parasites. Mullin KA, Lim L, ..., McFadden GI 10.1073/pnas.0602293103
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895