Product Description: ND6 protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Process | GO:0006323 | DNA packaging |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.16 | 0.92 |
| Trophozoite | expressed | 0.41 | 0.77 |
| Schizont | expressed | 1.48 | 0.36 |
| Gametocyte | possibly expressed | 0.31 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0508500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.177 | MFS: -2.704 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1108100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I418
"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=0.06) with 1XA1 (Global RMSD=19.09)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 32 | 88 | 46 | 173 |
| disruptive | 117 | 295 | 137 | 373 |
| missense | 64 | 212 | 105 | 284 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 47 | 185 | 88 | 148 |
| disruptive | 200 | 591 | 260 | 501 |
| missense | 100 | 391 | 199 | 348 |
PlasmoDB Total SNPs: 384
Non-coding: 77 | Synonymous: 151 | Nonsynonymous: 156 | Stop Codon: 0
Protein Length: 2606 | Molecular Weight (kDa): 304.12
PDB ID(s): None
Isoelectric Point: 8.44
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000408 | Regulator of chromosome condensation, RCC1 |
| InterPro | IPR009091 | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II |
| PFam | PF00415 | Regulator of chromosome condensation, RCC1 |
| PFam | PF13540 | |
| Superfamily | SSF50985 | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 33495622 | An Alveolata secretory machinery adapted to parasite host cell invasion. | Aquilini E, Cova MM, ..., Lebrun M | 10.1038/s41564-020-00854-z |