PF3D7_0508600

Genome location: Pf3D7_05_v3:355,948..357,049(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.21	0.89
Trophozoite	expressed	0.23	0.86
Schizont	expressed	0.41	0.74
Gametocyte	expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0508600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.874 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1108200)

Relative Growth Rate: 0.98 ± 0.17
Confidence: 4.99

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1108200)

Modification: Disrupted | RMgm-2963

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8H8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112953

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	7	11	12
disruptive	33	55	25	47
missense	15	27	18	32

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	23	13	16
disruptive	58	97	45	78
missense	22	51	31	44

PlasmoDB Total SNPs: 64

Non-coding: 25 | Synonymous: 18 | Nonsynonymous: 20 | Stop Codon: 1

Protein Information

Protein Length: 262 | Molecular Weight (kDa): 30.256

UniProt ID(s): A0A5K1K8H8

PDB ID(s): None

Isoelectric Point: 10.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A