About Gene List

PF3D7_0508900 (AAP6)

Genome location: Pf3D7_05_v3:366,627..376,779(+)

Genome classification: Core

Function and Localization

Product Description: protein AAP6

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.17 0.92
Trophozoite possibly expressed 0.84 0.63
Schizont expressed 3.18 0.10
Gametocyte expressed 1.22 0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0508900

Resistome Missense Mutations: H712N

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.647 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133724

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 42 112 65 157
disruptive 286 649 302 695
missense 136 396 206 472

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 65 205 105 172
disruptive 497 1095 438 886
missense 228 704 288 538

PlasmoDB Total SNPs: 760

Non-coding: 65 | Synonymous: 322 | Nonsynonymous: 367 | Stop Codon: 6

Protein Information

Protein Length: 3134 | Molecular Weight (kDa): 370.181

UniProt ID(s): Q8I414

PDB ID(s): None

Isoelectric Point: 5.1

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
33830607 Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. Wichers JS, Wunderlich J, ..., Gilberger TW 10.1111/cmi.13341