Product Description: structural maintenance of chromosomes protein 4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000775 | chromosome, centromeric region |
| Component | GO:0000796 | condensin complex |
| Component | GO:0005634 | nucleus |
| Process | GO:0007076 | mitotic chromosome condensation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.16 | 0.93 |
| Trophozoite | expressed | 1.33 | 0.41 |
| Schizont | expressed | 0.71 | 0.65 |
| Gametocyte | expressed | 0.72 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0509100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.128 | MFS: -2.845 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1108700)
Modification: Mutated | RMgm-4754
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I413
"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=0.05) with 5H68 (Global RMSD=1.81)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101113
Most Similar Human Ortholog: C9J9E4
TM-align score: 0.91 | RMSD: 1.90
Seq Identity: 0.54 | Length: 151 / 1708
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000113810 | structural maintenance of chromosomes 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 49 | 38 | 69 |
| disruptive | 72 | 152 | 83 | 211 |
| missense | 36 | 95 | 59 | 143 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 105 | 37 | 87 |
| disruptive | 125 | 274 | 115 | 275 |
| missense | 53 | 173 | 90 | 182 |
PlasmoDB Total SNPs: 249
Non-coding: 78 | Synonymous: 80 | Nonsynonymous: 90 | Stop Codon: 1
Protein Length: 1708 | Molecular Weight (kDa): 201.668
UniProt ID(s): Q8I413
PDB ID(s): None
Isoelectric Point: 5.05
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003395 | RecF/RecN/SMC, N-terminal |
| InterPro | IPR010935 | SMCs flexible hinge |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036277 | SMCs flexible hinge superfamily |
| InterPro | IPR041738 | Structural maintenance of chromosomes 4, ABC domain, eukaryotic |
| PFam | PF02463 | RecF/RecN/SMC, N-terminal |
| PFam | PF06470 | SMCs flexible hinge |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF75553 | SMCs flexible hinge superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32049018 | Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and AreEssential for Parasite Proliferation and Transmission. | Pandey R, Abel S, ..., Tewari R | 10.1016/j.celrep.2020.01.033 |